Could USC or Oregon beat Gonzaga? Sure, Oregon has the wing depth to matchup with Gonzaga and USC has the elite athleticism big men Gonzaga doesn’t. But I definitely wouldn’t feel comfortable picking either of those two, I’d still take Gonzaga every game no matter who they played.
Baylor over Villanova seems like the easiest pick to me. Nova lost 3 of their last 4 games against Big East teams to Butler (with Gillespie), Providence and Georgetown. They’ve made the Sweet Sixteen by beating North Texas and Winthrop, two teams ranked below Providence and Georgetown by KP/Torvik. Guard depth was a problem for them before losing Gillespie, now they have to go against Jared Butler, Davion Mitchell, MaCio Teague and Adam Flagler. I think Baylor will win big.
Besides that Houston over Syracuse is the game I feel best about. Houston is just the better team in general, so the only reason to choose Cause over them would be you think the zone is going to mess with Houston. But Houston is the 2nd best offensive rebounding team and Syracuse it’s ranked around 300th in defensive rebounding. Seems like Houston will be getting easy 2nd chance buckets all day, should make it a fairly comfortable win for them IMO.